Juan E. Segura-Aguilar : rechercher sur Z-Library

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1

Cell Lines as In Vitro Models for Drug Screening and Toxicity Studies

Allen, David D., Caviedes, Raúl, Cárdenas, Ana María, Shimahara, Takeshi, Segura-Aguilar, Juan, Caviedes, Pablo A.

Journal:

Drug Development and Industrial Pharmacy

Année:

2005

Langue:

english

Fichier:

PDF, 288 KB

english, 2005

2

Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases

Costa, Silvia Lima, Silva, Victor Diogenes Amaral, dos Santos Souza, Cleide, Santos, Cleonice Creusa, Paris, Irmgard, Muñoz, Patricia, Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Année:

2016

Langue:

english

Fichier:

PDF, 620 KB

english, 2016

3

Reduction of Brain Antioxidant Defense Upon Treatment with Butylated Hydroxyanisole (BHA) and Sudan III in Syrian Golden Hamster

Francisco J. Romero, Joaquín Romá, Francisco Bosch-Morell, Belén Romero, Juan Segura-Aguilar, Antonio Llombart-Bosch, Lars Ernster

Journal:

Neurochemical Research

Année:

2000

Langue:

english

Fichier:

PDF, 21 KB

english, 2000

4

Nitrobenzimidazoles as Substrates for DT-Diaphorase and Redox Cycling Compounds: Their Enzymatic Reactions and Cytotoxicity

Jonas šarlauskas, Egl≐ Dičkancait≐, Aušra Nemeikait≐, Žilvinas Anusevičius, Henrikas Nivinskas, Juan Segura-Aguilar, Narimantas č≐nas

Journal:

Archives of Biochemistry and Biophysics

Année:

1997

Langue:

english

Fichier:

PDF, 206 KB

english, 1997

5

Dopamine Oxidation and Autophagy

Muñoz, Patricia, Huenchuguala, Sandro, Paris, Irmgard, Segura-Aguilar, Juan

Journal:

Parkinson's Disease

Année:

2012

Langue:

english

Fichier:

PDF, 3.15 MB

english, 2012

6

ChemInform Abstract: The Role of Metal Ions in Dopaminergic Neuron Degeneration in Parkinsonism and Parkinson′s Disease

Irmgard Paris, Juan Segura-Aguilar

Journal:

Année:

2011

Fichier:

PDF, 18 KB

2011

7

Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome

Ana María Cárdenas, David D. Allen, Christian Arriagada, Alexis Olivares, Lori B. Bennett, Raúl Caviedes, Alexies Dagnino-Subiabre, Isabel E. Mendoza, Juan Segura-Aguilar, Stanley I. Rapoport, Pablo C

Journal:

Journal of Neuroscience Research

Année:

2002

Langue:

english

Fichier:

PDF, 486 KB

english, 2002

8

Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome

Patricia Opazo, Katherine Saud, Michelle de Saint Pierre, Ana María Cárdenas, David D. Allen, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Journal of Neuroscience Research

Année:

2006

Langue:

english

Fichier:

PDF, 307 KB

english, 2006

9

Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line

Irmgard Paris, Alexies Dagnino-Subiabre, Katherine Marcelain, Lori B. Bennett, Pablo Caviedes, Raúl Caviedes, Claudio Olea Azar, Juan Segura-Aguilar

Journal:

Journal of Neurochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 694 KB

english, 2001

10

Oxygen toxicity in the nervous tissue: Comparison of the antioxidant defense of rat brain and sciatic nerve

Francisco J. Romero, Elena Monsalve, Carlos Hermenegildo, Francisco J. Puertas, Victoria Higueras, Eberhard Nies, Juan Segura-Aguilar, Joaquín Romá

Journal:

Neurochemical Research

Année:

1991

Langue:

english

Fichier:

PDF, 494 KB

english, 1991

11

The possible role of one-electron reduction of aminochrome in the neurodegenerative process of the dopaminergic system

Juan Segura-Aguilar, Diana Metodiewa, Sofia Baez

Journal:

Neurotoxicity Research

Année:

2001

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2001

12

Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats

Diego Bustamante, L. Bustamante, Juan Segura-Aguilar, Michel Goiny, Mario Herrera-Marschitz

Journal:

Neurotoxicity Research

Année:

2003

Langue:

english

Fichier:

PDF, 689 KB

english, 2003

13

Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. A review

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2003

Langue:

english

Fichier:

PDF, 281 KB

english, 2003

14

Neurotoxins and neurotoxicity mechanisms. an overview

Juan Segura-Aguilar, Richard M. Kostrzewa

Journal:

Neurotoxicity Research

Année:

2006

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2006

15

Neurotoxins and neurotoxic species implicated in neurodegeneration

Juan Segura-Aguilar, Richard M. Kostrzewa

Journal:

Neurotoxicity Research

Année:

2004

Langue:

english

Fichier:

PDF, 179 KB

english, 2004

16

Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson’s disease

Irmgard Paris, Sergio Cardenas, Jorge Lozano, Carolina Perez-Pastene, Rebecca Graumann, Alejandra Riveros, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2007

Langue:

english

Fichier:

PDF, 825 KB

english, 2007

17

Botulinum neurotoxin: Evolution from poison, to research tool - onto medicinal therapeutic and future pharmaceutical panacea

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2007

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2007

18

The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease

Irmgard Paris, Juan Segura-Aguilar

Journal:

Monatshefte für Chemie - Chemical Monthly

Année:

2011

Langue:

english

Fichier:

PDF, 1013 KB

english, 2011

19

Molecular and Neurochemical Mechanisms in PD Pathogenesis

Irmgard Paris, Jorge Lozano, Carolina Perez-Pastene, Patricia Muñoz, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2009

Langue:

english

Fichier:

PDF, 269 KB

english, 2009

20

Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

Irmgard Paris, Carolina Perez-Pastene, Sergio Cardenas, Patricio Iturriaga-Vasquez, Patricia Muñoz, Eduardo Couve, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2010

Fichier:

PDF, 86 KB

2010

21

Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

Irmgard Paris, Carolina Perez-Pastene, Sergio Cardenas, Patricio Iturra, Patricia Muñoz, Eduardo Couve, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2010

Langue:

english

Fichier:

PDF, 631 KB

english, 2010

22

Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra

Irmgard Paris, Pedro Martinez-Alvarado, Carolina Perez-Pastene, Marcelo N. N. Vieira, Claudio Olea-Azar, Rita Raisman-Vozari, Sergio Cardenas, Rebeca Graumann, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Journal of Neurochemistry

Année:

2005

Langue:

english

Fichier:

PDF, 430 KB

english, 2005

23

Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome

Alexies Dagnino-Subiabre, Katerine Marcelain, Christian Arriagada, Irmgard Paris, Pablo Caviedes, Raul Caviedes, Juan Segura-Aguilar

Journal:

Molecular and Cellular Biochemistry

Année:

2000

Langue:

english

Fichier:

PDF, 205 KB

english, 2000

24

Interplay Between CYP3A-Mediated Metabolism and Polarized Efflux of Terfenadine and Its Metabolites in Intestinal Epithelial Caco-2 (TC7) Cell Monolayers

Shamsi D. Raeissi, Ismael J. Hidalgo, Juan Segura-Aguilar, Per Artursson

Journal:

Pharmaceutical Research

Année:

1999

Fichier:

PDF, 1.32 MB

1999

25

Program and abstracts of the First Int’l Meeting: Mechanisms for Neurodegenerative Disorders—Alzheimer, Amyotropic Lateral Sclerosis (ALS) and Parkinson’s Disease

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2002

Langue:

english

Fichier:

PDF, 1.90 MB

english, 2002

26

Neurotoxicological and neuroprotective elements in Parkinson’s disease

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Année:

2002

Langue:

english

Fichier:

PDF, 411 KB

english, 2002

27

Peroxidase Activity of Liver Microsomal Vitamin D 25-Hydroxylase and Cytochrome P450 1A2 Catalyzes 25-Hydroxylation of Vitamin D3and Oxidation of Dopamine to Aminochrome

Juan Segura-Aguilar

Journal:

Biochemical and Molecular Medicine

Année:

1996

Langue:

english

Fichier:

PDF, 139 KB

english, 1996

28

Effects of Four Organohalogen Environmental Contaminants on Cytochrome P450 Forms That Catalyze 4- and 2-Hydroxylation of Estradiol in the Rat Liver

Juan Segura-Aguilar, Victor Castro, Åke Bergman

Journal:

Biochemical and Molecular Medicine

Année:

1997

Langue:

english

Fichier:

PDF, 94 KB

english, 1997

29

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

Pabla Aguirre, Pamela Urrutia, Victoria Tapia, Monica Villa, Irmgad Paris, Juan Segura-Aguilar, Marco T. Núñez

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 421 KB

english, 2012

30

Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson’s Disease

Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizabi

Journal:

Neurotoxicity Research

Année:

2012

Langue:

english

Fichier:

PDF, 259 KB

english, 2012

31

Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome

Mario A. Acuña, Ramón Pérez-Nuñez, Jorge Noriega, Ana María Cárdenas, Juan Bacigalupo, Ricardo Delgado, Christian Arriagada, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Neurotoxicity Research

Année:

2012

Langue:

english

Fichier:

PDF, 551 KB

english, 2012

32

On the mechanism of the Mn3+-induced neurotoxicity of dopamine: Prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase

Juan Segura-Aguilar, Christina Lind

Journal:

Chemico-Biological Interactions

Année:

1989

Langue:

english

Fichier:

PDF, 778 KB

english, 1989

33

A new direct method for determining superoxide dismutase activity by measuring hydrogen peroxide formation

Juan Segura-Aguilar

Journal:

Chemico-Biological Interactions

Année:

1993

Langue:

english

Fichier:

PDF, 488 KB

english, 1993

34

Superoxide dismutase and catalase prevent the formation of reactive oxygen species during reduction of cyclized dopa ortho-quinone by DT-diaphorase

Sofia Baez, Ylva Linderson, Juan Segura-Aguilar

Journal:

Chemico-Biological Interactions

Année:

1994

Langue:

english

Fichier:

PDF, 641 KB

english, 1994

35

The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60)

Juan Segura-Aguilar, Kerstin Jönsson, Ulf Tidefelt, Christer Paul

Journal:

Leukemia Research

Année:

1992

Langue:

english

Fichier:

PDF, 586 KB

english, 1992

36

Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol

Juan Segura-Aguilar, Rudolf Kaiser, Christina Lind

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1992

Langue:

english

Fichier:

PDF, 863 KB

english, 1992

37

DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides

Anders Brunmark, Enrique Cadenas, Juan Segura-Aguilar, Christina Lind, Lars Ernster

Journal:

Free Radical Biology and Medicine

Année:

1988

Langue:

english

Fichier:

PDF, 866 KB

english, 1988

38

Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

Francisco J. Romero, Juan Segura-Aguilar, Elena Monsalve, Carlos Hermenegildo, Eberhard Nies, Francisco J. Puertas, Joaquín Romá

Journal:

Neurotoxicology and Teratology

Année:

1990

Langue:

english

Fichier:

PDF, 298 KB

english, 1990

39

Knockdown of amyloid precursor protein gene corrects altered intracellular Ca2+ signals in a cell line derived from the cerebral cortex of trisomy 16 mouse: An animal model of Down syndrome

Gonzalo Encina, Christian Arriagada, Patricia Opazo, Guillermo Rojas, Michelle de Saint Pierre, Ana María Cárdenas, Takeshi Shimahara, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Journal of Physiology-Paris

Année:

2006

Langue:

english

Fichier:

PDF, 79 KB

english, 2006

40

Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor

Gabriela Dı&amp, #x0301, az-Véliz, Sergio Mora, Patricia Gómez, Ma Teresa Dossi, Juan Montiel, Christian Arriagada, Francisco Aboitiz, Juan Segura-Aguilar

Journal:

Pharmacology Biochemistry and Behavior

Année:

2004

Langue:

english

Fichier:

PDF, 368 KB

english, 2004

41

DT-Diaphorase Maintains the Reduced State of Ubiquinones in Lipid Vesicles thereby Promoting their Antioxidant Function

Laura Landi, Diana Fiorentini, M.Cristina Galli, Juan Segura-Aguilar, Robert E Beyer

Journal:

Free Radical Biology and Medicine

Année:

1997

Langue:

english

Fichier:

PDF, 373 KB

english, 1997

42

Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

Diana Metodiewa, Anil K. Jaiswal, Narimantas Cenas, Egle Dickancaité, Juan Segura-Aguilar

Journal:

Free Radical Biology and Medicine

Année:

1999

Langue:

english

Fichier:

PDF, 225 KB

english, 1999

43

Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity

Lozano, Jorge, Muñoz, Patricia, Nore, Beston F., LeDoux, Susan, Segura-Aguilar, Juan

Journal:

Chemical Research in Toxicology

Année:

2010

Langue:

english

Fichier:

PDF, 177 KB

english, 2010

44

Glutathione Transferase M2-2 Catalyzes Conjugation of Dopamine and Dopa o-Quinones

Alexies Dagnino-Subiabre, Bruce K. Cassels, Sofia Baez, Ann-Sofie Johansson, Bengt Mannervik, Juan Segura-Aguilar

Journal:

Biochemical and Biophysical Research Communications

Année:

2000

Langue:

english

Fichier:

PDF, 67 KB

english, 2000

45

Possible Role of Salsolinol Quinone Methide in the Decrease of RCSN-3 Cell Survival

Pedro Martinez-Alvarado, Alexies Dagnino-Subiabre, Irmgard Paris, Diana Metodiewa, Christopher J. Welch, Claudio Olea-Azar, Pablo Caviedes, Raul Caviedes, Juan Segura-Aguilar

Journal:

Biochemical and Biophysical Research Communications

Année:

2001

Langue:

english

Fichier:

PDF, 176 KB

english, 2001

46

Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes

Juan E. Segura-Aguilar, Virginia Barreiro, Christina Lind

Journal:

Archives of Biochemistry and Biophysics

Année:

1986

Langue:

english

Fichier:

PDF, 892 KB

english, 1986

47

Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity

Patricia Muñoz, Irmgard Paris, Laurie H. Sanders, J. Timothy Greenamyre, Juan Segura-Aguilar

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2012

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2012

48

Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse

Guillermo Rojas, Ana María Cárdenas, Paola Fernández-Olivares, Takeshi Shimahara, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Experimental Neurology

Année:

2008

Langue:

english

Fichier:

PDF, 570 KB

english, 2008

49

Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism

Zilvinas Anusevicius, Ans E.M.F Soffers, Narimantas Cénas, Jonas Sarlauskas, Juan Segura-Aguilar, Ivonne M.C.M Rietjens

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 111 KB

english, 1998

50

DT-diaphorase catalyzes N-denitration and redox cycling of tetryl

Žilvinas Anusevičius, Jonas Šarlauskas, Henrikas Nivinskas, Juan Segura-Aguilar, Narimantas Č≐nas

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 162 KB

english, 1998